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100,000 Genomes Project pinpoints new cancer genetic culprits

DNA analysis of thousands of tumours in the 100,000 Genomes project has uncovered a ‘treasure trove’ of 58 new mutational signatures causing cancer. The study, published in Science, 21 April, showed that…

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IL-6 provides missing link between exercise and colon cancer protection

Interleukin-6 (IL-6) molecules released into the systemic circulation during exercise elicit biological effects limiting colon cancer cell proliferation. The UK study, published in International Journal of Cancer, 7 April, provides a potential…

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CAR T-cell therapy shows efficacy in solid tumours

A CAR T-cell therapy first-in-human study demonstrated early signs of efficacy for patients with a range of solid tumours, including testicular and ovarian cancers. The study, presented at the American Academy of…

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No link between brain tumours and ‘usual’ use of mobile phones

‘Usual’ use of mobile phones does not increase the incidence of brain tumours. The prospective study, published in the Journal of the National Cancer Institute, 30 March 2022, found no statistically significant…

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Radiologists urged to report breast arterial calcification for CVD prevention

Routine mammograms could be used to provide additional information about women’s risk of cardiovascular disease (CVD). The study, published in ‘Circulation: Cardiovascular imaging’, March 15, found women with breast arterial calcification had…

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Colorectal cancer linked to lifetime of excess weight

Cumulative lifetime exposure to excess weight accounts for a larger share of Colorectal cancer (CRC) risk than previously appreciated. The German study, published in JAMA Oncology, 17 March, demonstrates the importance of…

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European Cancer Community urged to sign-up to help Ukrainian patients

The European Cancer Organisation (ECO) and American Society of Clinical Oncology (ASCO) have launched a network to provide an infrastructure to support Ukrainian cancer patients. The Special Network on the Impact of…

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No reason to delay cancer immunotherapy following antibiotic use

Exposure to antibiotics prior to anti-PD-1 antibody treatment had no effect on melanoma outcomes.  The French study, reported in the Journal of the National Cancer Institute (published March 7, 2022), found using…

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Harmful bacteria play greater role in predicting outcomes of immune checkpoint blockade in melanoma

Harmful gut bacteria may play a greater role than beneficial bacteria in determining efficacy of immune checkpoint blockade in melanoma patients. The study, published in Nature Medicine (28 February), found microbial signatures…

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Starting age for MRI breast screening defined for three genetic mutations

Annual magnetic resonance imaging (MRI) starting from age 30 to 35 years followed by combined annual MRI and mammography from age 40 may reduce breast cancer mortality by over 50% for women…