immune checkpoint blockade (ICB)

News

Harmful bacteria play greater role in predicting outcomes of immune checkpoint blockade in melanoma

Harmful gut bacteria may play a greater role than beneficial bacteria in determining efficacy of immune checkpoint blockade in melanoma patients. The study, published in Nature Medicine (28 February), found microbial signatures…

Articles

Immunotherapy toxicities demand a joined up approach from oncologists and organ specialists

Adverse effects of cancer therapies have long been at the root of decision making for interventions in all modalities – surgery, radiotherapy and medical – and especially in the latter category of…

News

Preclinical model identifies predictors of checkpoint inhibitor response

A study published in PNAS (Chen IX, et al. PNAS 2020) of a new mouse model has enabled the identification of distinct gene signatures that distinguish responders from non-responders to immune checkpoint blockade (ICB). “Our findings provide a general approach for investigating mechanisms of resistance to ICB and identifying predictive biomarkers of response,” write the […]