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Five San Antonio take-aways to improve care of breast cancer patients

The 2022 San Antonio Breast Cancer Symposium, hosted in association with the American Association for Cancer Research (AACR), was held December 6–10, 2022. More than 8,000 researchers, clinicians, students, and patient advocates…

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Repurposed drug combination reduces risk of recurrence following surgery for colorectal cancer

Pharmacological suppression of adrenergic and inflammatory signalling using readily available drugs to lower blood pressure and reduce anxiety decreased the risk of post-surgical colorectal cancer (CRC) recurrence. The pilot COMPIT study, published…

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Aerobic activity to outcompete metastasis 

Aerobic exercise can reduce the risk of developing metastatic cancer by 73%. Using both human epidemiological data and in vivo mouse models of melanoma metastasis, Israeli investigators report in Cancer Research (November…

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Biological differences revealed between dense and nondense breast tissue

Postmenopausal women with dense breast tissue compared to women of the same age who do not have dense tissue demonstrate upregulation of 124 proteins which may be responsible for creating pro-tumorigenic microenvironments.…

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Knowing ‘functional prognosis’ helps cancer patients plan unfinished business

More cancer patients want to be informed about their future functional prognosis than their life expectancy. The Japanese survey, published in Annals of Palliative Medicine, October 28,  found that almost half of…

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New target identified for preventing cachexia

Targeting a specific enzyme in muscle could help cancer patients avoid the muscle wasting condition cachexia. The study, published in PNAS (October 17), found that a previously overlooked enzyme, known as UBR2,…

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Radiotherapy benefits survival in patients with asymptomatic metastases

Treating high-risk, asymptomatic bone metastases with prophylactic radiation therapy reduces painful complications and extends overall survival. The study, abstract LBA 04, presented at the American Society for Radiation Oncology (ASTRO) Annual Meeting,…

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Fungal communities are a key part of cancer cell biology

The first pan-cancer mycobiome atlas has revealed the presence of microfungi in 35 types of cancer, with the presence of some fungi correlating with overall survival. The findings of associations between cancer…

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Melanoma: treatment sequence matters

Patients with metastatic melanoma who received immunotherapy before targeted therapy showed a 20% overall survival advantage at two years versus those receiving targeted therapy first, with immunotherapy after. The final results of…

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Cancer metastasis hijacks process healthy cells use to move around the body

Blocking the activity of an ion channel in a mouse model of cancer triggered metastasis independent of tumour formation. The study, published in Nature Genetics, 29th September, found that the process was…