News

Using ultrasound to open blood–brain barrier could be glioblastoma game changer

A novel ultrasound device temporarily opens the blood–brain barrier to allow delivery of chemotherapy. The dose-escalation phase 1 study, published in Lancet Oncology, May 2, provides evidence that use of the new…

News

Genetic targets identified for cancer-associated cachexia

Distinct patterns of genes have been shown to be active in the tumours of non-small-cell lung cancer patients who go on to develop cachexia, including high activity of the protein GDF15. The…

News

Antimicrobial exposure linked to poorer survival in triple negative breast cancer

Each additional total or unique monthly antimicrobial prescription is associated with inferior overall and breast-cancer-specific survival in women with triple negative breast cancer (TNBC). The study published in Nature Communications, 12 April…

News

Trial platform informs precision treatment of childhood cancers

A stratified medicine basket study has shown the benefit of combining two targeted therapies to treat paediatric cancers with specific molecular profiles. The study, presentation number CT019, presented at the AACR (American…

News

Personalised RNA vaccine combined with immune checkpoint inhibitor shows efficacy in melanoma

In advanced melanoma, adding a personalised mRNA-based vaccine to the immune checkpoint inhibitor pembrolizumab improved recurrence-free survival compared with pembrolizumab alone. The KEYNOTE-942 study (presentation number CT001), presented at the AACR (American…

News

Intermittent dosing of exemestane is non-inferior to daily dosing

Giving the aromatase inhibitor (AI) exemestane 25 mg three times weekly was non-inferior to the standard dosing of 25mg daily among study participants who complied with the schedule. The international, multicentric study,…

News

Body weight influences breast cancer risk in women with BRCA1 and 2 mutations

Obesity may be a factor contributing to DNA damage in the breast tissue of women with BRCA1 or BRCA2 mutations. The study, published in Science Translational Medicine, February 22, suggests maintaining a…

News

Improving outcomes in elderly patients taking multiple medications

For older patients with cancer, taking multiple medications can result in toxic chemotherapy side effects and even the need to stop cancer treatment. The cohort study, published in Cancer, 24th January, found…

News

Localised prostate cancer: active monitoring offers valid option

Active monitoring of localised prostate cancer has the same high rates of survival after 15 years as radiotherapy or surgery. The ProtecT trial, presented at the European Association of Urology (EAU) meeting…

Articles

Immunotherapy: three studies point to potential strategies to improve response

Over the past 10 years, immune checkpoint inhibitors (ICIs) have transformed the therapeutic landscape of cancer, becoming standard treatments for metastatic melanoma, renal cell carcinoma, head and neck cancer, and non-small cell…