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How a Brain-Destroying Protein Became Cancer’s Ally: Alpha-Synuclein Emerges as a New Target in Melanoma

The alpha-synuclein, a protein long associated with Parkinson’s disease may hold the key to melanoma proliferation. The study, published in Science Advances, on 9 April, suggests that while excess alpha-synuclein results in…

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Microbiota-Derived Bile Acids as Androgen Receptor Antagonists Enhance Anti-Tumour Immunity

The gut microbiota can transform cholesterol-derived bile acids into metabolites capable of blocking androgen receptors and strengthening anti-cancer immunity. The study, published in Cell, April 15, demonstrates how one of the microbiota-derived…

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Strategies Needed to Prioritise Screening in Survivors of Childhood Cancer

Survivors of childhood cancer experience accelerated onset of ageing-related diseases, regardless of prior radiation exposure. The simulation modelling study, published in JAMA Oncology, online March 20, found that chronic health conditions developed…

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Common Diabetes Medication Could Protect Heart Health During Cancer Treatment

Sodium-glucose cotransporter 2 (SGLT2) inhibitors, a common type of diabetes medication, may protect the heart during and after cancer treatment. The systematic review and meta-analysis, published in European Journal of Preventive Cardiology…

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Personalised neoantigen vaccine for kidney cancer shows promise in phase 1 study

Personalised neoantigen cancer vaccines (both with and without ipilimumab) elicited anticancer immune responses in nine patients with fully resected clear cell renal cell carcinoma. The investigator-initiated phase 1 trial, published in Nature,…

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What Caught Our Eye in April: Oncology’s Top Moments

April 2025 marked a significant month in oncology, with notable advancements in cancer treatment and research. Here’s a summary of the most compelling studies and recent breakthroughs that caught our eye this…

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It’s no longer taboo to suggest that some metastatic breast cancers may be curable

It’s long been clear that, in most patients with metastatic HER-positive breast cancer, adding effective HER2 blockade to cytotoxics can result in very prolonged responses. Janet Fricker reports on the prospective trials…

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What Caught Our Eye in March: Oncology’s Top Moments

March saw the publication of several important studies in oncology, shedding new light on cancer treatment and care. Here’s a roundup of the key studies on recent discoveries and breakthroughs that grabbed…

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Ovarian cancer: mechanism conferring resistance to immunotherapy revealed

The presence of flagella, the propellers bacteria use to move, explains why immune checkpoint inhibitors do not work in patients with ovarian cancer. The study, published in Cancer Immunology Research, 11 February,…

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Muscular strength and cardiorespiratory fitness improve survival in cancer patients

Muscular strength and cardiorespiratory fitness are linked to a significantly lower risk of death from any cause and cancer-specific mortality in patients diagnosed with cancer. The meta-analysis, published online in the British…