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Low-dose aspirin reduces colorectal cancer recurrence in patients with PI3K alterations

Taking adjuvant low-dose aspirin daily for three years reduced recurrence of colorectal cancer by 55% in patients with somatic alterations in PI3K signalling compared to those taking placebo. The results of the…

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MRI technique can identify pre-malignant pancreatic lesions

Diffusion tensor imaging (DTI), a form of MRI, is capable of detecting pre-malignant lesions in both mouse and human pancreatic specimens. The ‘proof of concept’ study, published in Investigative Radiology, 13 December…

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Key link identified in mechanism promoting lung metastases from breast cancer

The amino acid aspartate has been found to function as an extracellular signalling molecule to promote lung metastases in breast cancer. The study, published in Nature, 1 January, which was undertaken in…

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Second-generation BTK inhibitor shows promise as fixed-duration therapy in CLL

Treatment with the second-generation Bruton tyrosine kinase (BTK) inhibitor acalabrutinib plus the BCL2 inhibitor venetoclax (with or without the CD20 inhibitor obinutuzumab), delivered as fixed-duration therapies, significantly improved progression free survival in…

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New evidence can help inform decisions on managing early-onset breast cancer linked to BRCA mutations

Patients with germline BRCA gene mutations and a history of early-onset breast cancer who underwent risk-reducing bilateral mastectomy and/or a risk-reducing salpingo-oophorectomy had lower rates of death than those not undergoing these…

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Gut microbiota influence effectiveness of tamoxifen in breast cancer

Variations in the microbiota of the human gut impact on the pharmacokinetics of tamoxifen in the blood and consequently on the effectiveness of breast cancer prevention. The study, published in the journal…

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Radiotherapy prior to immunotherapy is the best treatment sequence for melanoma related brain metastases

Patients with melanoma related brain metastases achieve reduced risk of progression and better overall survival if they receive radiotherapy before immunotherapy as opposed to the other way round. The meta-analysis study, abstract…

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Study helps solve the puzzle of checkpoint inhibitor myocarditis

The immune reaction that occurs in the hearts of patients taking checkpoint inhibitors who develop immune checkpoint myocarditis may be distinct from the immune responses occurring in the tumours of these patients.…

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Smoking cessation fundamental to first-line cancer care

Cancer patients who enter a smoking cessation programme within six months of receiving a diagnosis, and quit within three months after programme entry, experience a 26% reduction in mortality versus those who…

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Large-scale whole genome sequencing identifies six new cancer susceptibility/ resistance  genes

Six previously unreported genes have been revealed to harbour rare germline mutations that associate with cancer risk. The study, published in Nature Genetics, 29 October, identified 34 genes associated with cancer risk,…